Emerging Roles of Arf-Like GTP-Binding Proteins: From Membrane Trafficking to Cytoskeleton Dynamics and Beyond

  • Mahak Sharma Indian Institute of Science Education and Research Mohali https://orcid.org/0000-0002-4117-4790
  • Rituraj Rituraj Marwaha Indian Institute of Science Education and Research (IISER) Mohali
  • Devashish Dwivedi Indian Institute of Science Education and Research (IISER) Mohali
Keywords: Arl GTPase, Membrane trafficking, Lysosome, Cilia


Arf-like (Arl) GTPases belong to the Ras superfamily of small GTPases with nearly 20 known members. As the name suggests, Arl GTPases were identified as proteins having a structure similar to ADP ribosylation factor (Arf) GTP-binding proteins. Despite having structurally resemblance to Arfs, Arl family members exhibit amazing diversity in mediating different cellular functions which makes them an attractive class of GTPases to study. Some of the examples include Arl3, Arl6 and Arl13b that are reported to be important for cilia biogenesis; Arl1 and Arl8 regulate the membrane trafficking pathways in cells; Arl11, a previously characterized tumor suppressor gene, is recently shown to be important for macrophage upon pathogen encounter. This review focuses on the known functions of Arl GTPases but there still remains a large gap in our understanding of how these Arls are regulated as well as the function of several Arl GTPases remains unknown.

Author Biography

Mahak Sharma, Indian Institute of Science Education and Research Mohali

2005-2009          Ph.D., Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska (U.S.A.)
2000-2004          B.Tech., Biotechnology, School of Biotechnology, Guru Gobind Singh Indraprastha University, New Delhi (India)

2018 (Apr)-present          Associate Professor, Department of Biological Sciences, IISER-M (India)
2012 (Oct)-present          Wellcome Trust/DBT-India Alliance Intermediate Fellow, Department of Biological Sciences, IISER-M (India)
2011 (Oct)-2018 (Mar)     Assistant Professor, Department of Biological Sciences, IISER-M (India)
2009-2011                          Postdoctoral Research Fellow, Harvard Medical School, Boston (U.S.A.)
2005-2009                          Graduate Research Assistant, University of Nebraska Medical Center, Omaha, Nebraska (U.S.A.)


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