Knowing Right From Wrong: Quality Control of Ribosome Biogenesis in Eubacteria

  • Sunil Shetty University of Basel
Keywords: Quality Control; Biogenesis; Bacteria


Ribosomes are amongst the largest molecular machines in any living cell, consist three ribosomal RNA (rRNA) over 50 ribosomal proteins (r-proteins). In bacteria they have a small subunit (30S) and a large subunit (50S) which together form a functional 70S ribosome, which translates the information in a messenger RNA (mRNA) into a polypeptide sequence. Translation occurs in multiple steps such as initiation, elongation, termination and recycling. The fidelity of these steps depends on the faithful assembly of the ribosome itself. The synthesis of ribosomes involves various processes such as folding and processing of rRNA, ordered loading of ribosomal proteins and modification of various critical residues in them. For accuracy of protein synthesis, a cell must ensure that the immature particles, are kept away from participating in active translation. And, once the ribosomes have been assembled, the cell must have a quality check to ensure the accuracy of the assembled particles. Defect in any of these processes will result in occurrence of the defective ribosomes in the translating pool, which in turn may lead to production of mis-translated proteins. In humans, genetic disorders of ribosomopathies occur because of deficiencies in ribosome biogenesis and quality control. Thus, it is crucial to understand the hitherto obscure mechanisms of quality control of ribosome biogenesis. This review is an attempt to provide an overview of the status of quality control mechanisms of ribosome biogenesis in prokaryotes.


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